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1

Inhibitory effects of flavonoid glycosides isolated from the peel of Japanese persimmon (Diospyros kaki Fuyu) on antigen-stimulated degranulation in rat basophilic leukaemia RBL-2H3 cells

Tomohiro Itoh, Kenji Ohguchi, Chizuru Nakajima, Masayoshi Oyama, Munekazu Iinuma, Yoshinori Nozawa, Yukihiro Akao, Masafumi Ito

Journal:

Year:

2011

Language:

english

File:

PDF, 754 KB

english, 2011

2

Cell Growth Inhibitory Effect of Cinnamic Acid Derivatives from Propolis on Human Tumor Cell Lines

Akao, Yukihiro, Maruyama, Hiroe, Matsumoto, Kenji, Ohguchi, Kenji, Nishizawa, Kumi, Sakamoto, Takashi, Araki, Yoko, Mishima, Satoshi, Nozawa, Yoshinori

Journal:

Biological & Pharmaceutical Bulletin

Year:

2003

Language:

english

File:

PDF, 106 KB

english, 2003

3

Inhibitory Effects of Flavonoid Glycosides Isolated from the Peel of Japanese Persimmon (Diospyros kaki ‘Fuyu’) on Melanin Biosynthesis

Ohguchi, Kenji, Nakajima, Chizuru, Oyama, Masayoshi, Iinuma, Munekazu, Itoh, Tomohiro, Akao, Yukihiro, Nozawa, Yoshinori, Ito, Masafumi

Journal:

Biological & Pharmaceutical Bulletin

Year:

2010

Language:

english

File:

PDF, 136 KB

english, 2010

4

Inhibitory effect of xanthones isolated from the pericarp of Garcinia mangostana L. on rat basophilic leukemia RBL-2H3 cell degranulation

Tomohiro Itoh, Kenji Ohguchi, Munekazu Iinuma, Yoshinori Nozawa, Yukihiro Akao

Journal:

Bioorganic & Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 1.04 MB

english, 2008

5

MicroRNA-143 and -145 in Colon Cancer

Akao, Yukihiro, Nakagawa, Yoshihito, Naoe, Tomoki

Journal:

DNA and Cell Biology

Year:

2007

Language:

english

File:

PDF, 474 KB

english, 2007

6

Anti-cancer effects of naturally occurring compounds through modulation of signal transduction and miRNA expression in human colon cancer cells

Kumazaki, Minami, Noguchi, Shunsuke, Yasui, Yuki, Iwasaki, Junya, Shinohara, Haruka, Yamada, Nami, Akao, Yukihiro

Journal:

The Journal of Nutritional Biochemistry

Year:

2013

Language:

english

File:

PDF, 2.08 MB

english, 2013

7

Anti-cancer fatty-acid derivative induces autophagic cell death through modulation of PKM isoform expression profile mediated by bcr-abl in chronic myeloid leukemia

Shinohara, Haruka, Taniguchi, Kohei, Kumazaki, Minami, Yamada, Nami, Ito, Yuko, Otsuki, Yoshinori, Uno, Bunji, Hayakawa, Fumihiko, Minami, Yosuke, Naoe, Tomoki, Akao, Yukihiro

Journal:

Year:

2015

Language:

english

File:

PDF, 2.87 MB

english, 2015

8

Two Related Cinnamic Acid Derivatives from Brazilian Honey Bee Propolis, Baccharin and Drupanin, Induce Growth Inhibition in Allografted Sarcoma S-180 in Mice

Mishima, Satoshi, Ono, Yosuke, Araki, Yoko, Akao, Yukihiro, Nozawa, Yoshinori

Journal:

Biological & Pharmaceutical Bulletin

Year:

2005

Language:

english

File:

PDF, 806 KB

english, 2005

9

Anti-Cancer Effects of Xanthones from Pericarps of Mangosteen

Akao, Yukihiro, Nakagawa, Yoshihito, Nozawa, Yoshinori

Journal:

International Journal of Molecular Sciences

Year:

2008

Language:

english

File:

PDF, 1.12 MB

english, 2008

10

Development and endoscopic appearance of colorectal tumors are characterized by the expression profiles of miRNAs

Nakagawa, Yoshihito, Akao, Yukihiro, Tahara, Tomomitsu, Yamashita, Hiromi, Nagasaka, Mitsuo, Shibata, Tomoyuki, Ohmiya, Naoki

Journal:

Medical Molecular Morphology

Year:

2018

Language:

english

File:

PDF, 1.82 MB

english, 2018

11

Molecular analysis of the rearranged genome and chimeric mRNAs caused by the t(6;11)(q27;q23) chromosome translocation involving MLL in an infant acute monocytic leukemia

Yukihiro Akao, Masaharu Isobe

Journal:

Genes, Chromosomes and Cancer

Year:

2000

Language:

english

File:

PDF, 158 KB

english, 2000

12

AAAP (ACNU, adriamycin, methotrexate, prednisolone) therapy for adult erythroleukemia. Report of three cases

Haruya Yoshikawa, Kunizo Maruo, Koichiro Nagata, Yukihiro Akao, Akikazu Hiraiwa, Satoshi Yoshikawa

Journal:

Year:

1982

Language:

english

File:

PDF, 1.97 MB

english, 1982

13

Expression of rck/p54, a DEAD-box RNA helicase, in gametogenesis and early embryogenesis of mice

Kenji Matsumoto, Oh-Yong Kwon, Hyungtae Kim, Yukihiro Akao

Journal:

Developmental Dynamics

Year:

2005

Language:

english

File:

PDF, 973 KB

english, 2005

14

Long-range mapping of the 11q23 region involved in chromosome aberrations in human tumors by pulsed-field gel electrophoresis with a yeast artificial chromosome

Dr. Yukihiro Akao, Yoshihide Tsujimoto, Masao Seto, Takashi Imai, Dominique Bergeron, Benoit Berbeau, Yoshinori Otsuki

Journal:

Genes, Chromosomes and Cancer

Year:

1993

Language:

english

File:

PDF, 448 KB

english, 1993

15

Negative regulation of melanogenesis by phospholipase D1 through mTOR/p70 S6 kinase 1 signaling in mouse B16 melanoma cells

Kenji Ohguchi, Yoshiko Banno, Yoshihito Nakagawa, Yukihiro Akao, Yoshinori Nozawa

Journal:

Journal of Cellular Physiology

Year:

2005

Language:

english

File:

PDF, 383 KB

english, 2005

16

A highly bioactive lignophenol derivative from bamboo lignin exhibits a potent activity to suppress apoptosis induced by oxidative stress in human neuroblastoma SH-SY5Y cells

Yukihiro Akao, Norio Seki, Yoshihito Nakagawa, Hong Yi, Kenji Matsumoto, Yukie Ito, Kuniyasu Ito, Masamitu Funaoka, Wakako Maruyama, Makoto Naoi, Yoshinori Nozawa

Journal:

Bioorganic & Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 669 KB

english, 2004

17

Preferential target is mitochondria in α-mangostin-induced apoptosis in human leukemia HL60 cells

Kenji Matsumoto, Yukihiro Akao, Hong Yi, Kenji Ohguchi, Tetsuro Ito, Toshiyuki Tanaka, Emi Kobayashi, Munekazu Iinuma, Yoshinori Nozawa

Journal:

Bioorganic & Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 709 KB

english, 2004

18

Identification of caffeoylquinic acid derivatives from Brazilian propolis as constituents involved in induction of granulocytic differentiation of HL-60 cells

Satoshi Mishima, Yoshikazu Inoh, Yukio Narita, Shozo Ohta, Takashi Sakamoto, Yoko Araki, Kazu-Michi Suzuki, Yukihiro Akao, Yoshinori Nozawa

Journal:

Bioorganic & Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 495 KB

english, 2005

19

Xanthones induce cell-cycle arrest and apoptosis in human colon cancer DLD-1 cells

Kenji Matsumoto, Yukihiro Akao, Kenji Ohguchi, Tetsuro Ito, Toshiyuki Tanaka, Munekazu Iinuma, Yoshinori Nozawa

Journal:

Bioorganic & Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 250 KB

english, 2005

20

The isolation of secondary metabolites and in vitro potent anti-cancer activity of clerodermic acid from Enicosanthum membranifolium

Mai Efdi, Tomohiro Itoh, Yukihiro Akao, Yoshinori Nozawa, Mamoru Koketsu, Hideharu Ishihara

Journal:

Bioorganic & Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 244 KB

english, 2007

21

Mechanism of the melanogenesis stimulation activity of (−)-cubebin in murine B16 melanoma cells

Noriko Hirata, Shunsuke Naruto, Kenji Ohguchi, Yukihiro Akao, Yoshinori Nozawa, Munekazu Iinuma, Hideaki Matsuda

Journal:

Bioorganic & Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 197 KB

english, 2007

22

Characterized mechanism of α-mangostin-induced cell death: Caspase-independent apoptosis with release of endonuclease-G from mitochondria and increased miR-143 expression in human colorectal cancer DLD-1 cells

Yoshihito Nakagawa, Munekazu Iinuma, Tomoki Naoe, Yoshinori Nozawa, Yukihiro Akao

Journal:

Bioorganic & Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 312 KB

english, 2007

23

Eupalinin A isolated from Eupatorium chinense L. induces autophagocytosis in human leukemia HL60 cells

Tomohiro Itoh, Yuko Ito, Kenji Ohguchi, Masayoshi Ohyama, Munekazu Iinuma, Yoshinori Otsuki, Yoshinori Nozawa, Yukihiro Akao

Journal:

Bioorganic & Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 1.39 MB

english, 2008

24

Interactive effects of polymethoxy flavones from Citrus on cell growth inhibition in human neuroblastoma SH-SY5Y cells

Yukihiro Akao, Tomohiro itoh, Kenji Ohguchi, Munekazu Iinuma, Yoshinori Nozawa

Journal:

Bioorganic & Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 846 KB

english, 2008

25

Inhibitory effects of polymethoxy flavones isolated from Citrus reticulate on degranulation in rat basophilic leukemia RBL-2H3: Enhanced inhibition by their combination

Tomohiro Itoh, Kenji Ohguchi, Munekazu Iinuma, Yoshinori Nozawa, Yukihiro Akao

Journal:

Bioorganic & Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 1.15 MB

english, 2008

26

Inhibitory effects of sesquiterpene lactones isolated from Eupatorium chinense L. on IgE-mediated degranulation in rat basophilic leukemia RBL-2H3 cells and passive cutaneous anaphylaxis reaction in mice

Tomohiro Itoh, Masayoshi Oyama, Norihiko Takimoto, Chihiro Kato, Yoshinori Nozawa, Yukihiro Akao, Munekazu Iinuma

Journal:

Bioorganic & Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 2.97 MB

english, 2009

27

Role of microRNA-143 in Fas-mediated apoptosis in human T-cell leukemia Jurkat cells

Yukihiro Akao, Yoshihito Nakagawa, Akio Iio, Tomoki Naoe

Journal:

Leukemia Research

Year:

2009

Language:

english

File:

PDF, 1.18 MB

english, 2009

28

Pauferrol A, a novel chalcone trimer with a cyclobutane ring from Caesalpinia ferrea mart exhibiting DNA topoisomerase II inhibition and apoptosis-inducing activity

Hiroshi Nozaki, Ken-ichiro Hayashi, Masahiro Kido, Kazuyuki Kakumoto, Shogo Ikeda, Nobuyasu Matsuura, Hiroyuki Tani, Daisuke Takaoka, Munekazu Iinuma, Yukihiro Akao

Journal:

Tetrahedron Letters

Year:

2007

Language:

english

File:

PDF, 120 KB

english, 2007

29

Arsenic induces apoptosis in B-cell leukaemic cell lines in vitro: activation of caspases and down-regulation of Bcl-2 protein

Yukihiro Akao, Hiromi Mizoguchi, Seiji Kojima, Tomoki Naoe, Nobuko Ohishi, Kunio Yagi

Journal:

British Journal of Haematology

Year:

1998

Language:

english

File:

PDF, 767 KB

english, 1998

30

A tumour-associated DEAD-box protein, rck/p54 exhibits RNA unwinding activity toward c-myc RNAs in vitro

Yukihiro Akao, Hitoshi Yoshida, Kenji Matsumoto, Tsutomu Matsui, Keita Hogetu, Nobuo Tanaka, Jiro Usukura

Journal:

Year:

2003

Language:

english

File:

PDF, 223 KB

english, 2003

31

Transfection-enforced Bcl-2 overexpression and an anti-Parkinson drug, rasagiline, prevent nuclear accumulation of glyceraldehyde-3-phosphate dehydrogenase induced by an endogenous dopaminergic neurotoxin, N-methyl(R)salsolinol

Wakako Maruyama, Yukihiro Akao, Moussa B. H. Youdim, Bruce A. Davis, Makoto Naoi

Journal:

Journal of Neurochemistry

Year:

2001

Language:

english

File:

PDF, 460 KB

english, 2001

32

Mitochondrial permeability transition mediates apoptosis induced by N-methyl(R)salsolinol, an endogenous neurotoxin, and is inhibited by Bcl-2 and rasagiline, N-propargyl-1(R)-aminoindan

Yukihiro Akao, Wakako Maruyama, Shigeomi Shimizu, Hong Yi, Yoshihito Nakagawa, Masayo Shamoto-Nagai, Moussa B. H. Youdim, Yoshihide Tsujimoto, Makoto Naoi

Journal:

Journal of Neurochemistry

Year:

2002

Language:

english

File:

PDF, 293 KB

english, 2002

33

Predominant expression of the src homology 2-containing tyrosine phosphatase protein SHP2 in vascular smooth muscle cells

Masaaki Adachi, Hiroaki Iwaki, Masanobu Shindoh, Yukihiro Akao, Takahisa Hachiya, Masako Ikeda

Journal:

Virchows Archiv

Year:

1997

Language:

english

File:

PDF, 602 KB

english, 1997

34

Immunohistochemical localization of cyclooxygenase and prostaglandin I2synthase in human female reproductive organs

Osamu Misaki, Shogo Tsubokura, Hiromichi Kubo, Minoru Ueki, Osamu Sugimoto, Yukihiro Akao, Yoshinori Otsuki

Journal:

Medical Molecular Morphology

Year:

1995

Language:

english

File:

PDF, 2.39 MB

english, 1995

35

Vaticanol C, a novel resveratrol tetramer, reduces lymph node and lung metastases of mouse mammary carcinoma carrying p53 mutation

Masa-Aki Shibata, Yukihiro Akao, Eiko Shibata, Yoshinori Nozawa, Tetsuro Ito, Satoshi Mishima, Junji Morimoto, Yoshinori Otsuki

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2007

Language:

english

File:

PDF, 710 KB

english, 2007

36

Gallic acid induces vascular smooth muscle cell death via hydroxyl radical production

Xinbin Qiu, Genzou Takemura, Masatoshi Koshiji, Yukihiro Hayakawa, Motoo Kanoh, Rumi Maruyama, Yasushi Ohno, Shinya Minatoguchi, Seigou Akao, Kazunori Fukuda, Takako Fujiwara, H. Fujiwara

Journal:

Heart and Vessels

Year:

2000

Language:

english

File:

PDF, 1010 KB

english, 2000

37

Mitochondria in neurodegenerative disorders: regulation of the redox state and death signaling leading to neuronal death and survival

Makoto Naoi, Wakako Maruyama, Hong Yi, Keiko Inaba, Yukihiro Akao, Masayo Shamoto-Nagai

Journal:

Journal of Neural Transmission

Year:

2009

Language:

english

File:

PDF, 503 KB

english, 2009

38

Involvement of calpain in melanogenesis of mouse B16 melanoma cells

Kenji Ohguchi, Yukihiro Akao, Yoshinori Nozawa

Journal:

Molecular and Cellular Biochemistry

Year:

2005

Language:

english

File:

PDF, 230 KB

english, 2005

39

Inhibitory effects of flavonoids isolated from Fragaria ananassa Duch on IgE-mediated degranulation in rat basophilic leukemia RBL-2H3

Tomohiro Itoh, Masayuki Ninomiya, Masaharu Yasuda, Kaneyuki Koshikawa, Yoshihiro Deyashiki, Yoshinori Nozawa, Yukihiro Akao, Mamoru Koketsu

Journal:

Bioorganic & Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 939 KB

english, 2009

40

Involvement of heme oxygenase-1 induction via Nrf2/ARE activation in protection against H2O2-induced PC12 cell death by a metabolite of sesamin contained in sesame seeds

Nanako Hamada, Arisa Tanaka, Yasunori Fujita, Tomohiro Itoh, Yoshiko Ono, Yoshinori Kitagawa, Namino Tomimori, Yoshinobu Kiso, Yukihiro Akao, Yoshinori Nozawa, Masafumi Ito

Journal:

Bioorganic & Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 533 KB

english, 2011

41

Allicin inhibits cell growth and induces apoptosis through the mitochondrial pathway in HL60 and U937 cells

Talia Miron, Meir Wilchek, Ayala Sharp, Yoshihito Nakagawa, Makoto Naoi, Yoshinori Nozawa, Yukihiro Akao

Journal:

The Journal of Nutritional Biochemistry

Year:

2008

Language:

english

File:

PDF, 662 KB

english, 2008

42

Molecular Cloning of 19p13 Breakpoint Region in Infantile Leukemia with t(11;19)(q23;p13) Translocation

Shinsuke Iida, Masao Seto, Kazuhito Yamamoto, Hirokazu Komatsu, Yukihiro Akao, Shinpei Nakazawa, Yutaka Ariyoshi, Toshitada Takahashi, Ryuzo Ueda

Journal:

Year:

1993

File:

PDF, 361 KB

1993

43

Antitumor effect of arsenic trioxide in murine xenograft model

Mariko Kito, Kenji Matsumoto, Naoko Wada, Kouichiro Sera, Shoji Futatsugawa, Tomoki Naoe, Yoshinori Nozawa, Yukihiro Akao

Journal:

Year:

2003

Language:

english

File:

PDF, 1.66 MB

english, 2003

44

Downregulation of microRNAs-143 and -145 in B-cell malignancies

Yukihiro Akao, Yoshihito Nakagawa, Yukio Kitade, Tomohiro Kinoshita, Tomoki Naoe

Journal:

Year:

2007

Language:

english

File:

PDF, 496 KB

english, 2007

45

Structural insight of human DEAD-box protein rck/p54 into its substrate recognition with conformational changes

Tsutomu Matsui, Keita Hogetsu, Jiro Usukura, Takao Sato, Takashi Kumasaka, Yukihiro Akao, Nobuo Tanaka

Journal:

Year:

2006

Language:

english

File:

PDF, 522 KB

english, 2006

46

Type A monoamine oxidase is the target of an endogenous dopaminergic neurotoxin, N-methyl(R)salsolinol, leading to apoptosis in SH-SY5Y cells

Hong Yi, Yukihiro Akao, Wakako Maruyama, Kavin Chen, Jean Shih, Makoto Naoi

Journal:

Journal of Neurochemistry

Year:

2006

Language:

english

File:

PDF, 278 KB

english, 2006

47

Neuromelanin selectively induces apoptosis in dopaminergic SH-SY5Y cells by deglutathionylation in mitochondria: involvement of the protein and melanin component

Makoto Naoi, Wakako Maruyama, Hong Yi, Yuriko Yamaoka, Masayo Shamoto-Nagai, Yukihiro Akao, Manfred Gerlach, Masashi Tanaka, Peter Riederer

Journal:

Journal of Neurochemistry

Year:

2008

Language:

english

File:

PDF, 582 KB

english, 2008

48

Lig-8, a Highly Bioactive Lignophenol Derivative from Bamboo Lignin, Exhibits Multifaceted Neuroprotective Activity

Yasushi Ito, Yukihiro Akao, Masamitsu Shimazawa, Norio Seki, Yoshinori Nozawa, Hideaki Hara

Journal:

CNS Drug Reviews

Year:

2007

Language:

english

File:

PDF, 5.99 MB

english, 2007

49

Oxidative stress in mitochondria

Makoto Naoi, Wakako Maruyama, Masayo Shamoto-Nagai, Hong Yi, Yukihiro Akao, Masashi Tanaka

Journal:

Molecular Neurobiology

Year:

2005

Language:

english

File:

PDF, 379 KB

english, 2005

50

Expression of two dead box gene (DDX1 amd DDX6) is independent of that of MYCN in human neuroblastoma cell lines

Kiyotaka Akiyama, Yukihiro Akao, Masahiro Yokoyama, Yoshihito Nakagawa, Tohru Noguchi, Kunio Yagi, Yoshisuke Nishi

Journal:

Year:

1999

Language:

english

File:

PDF, 397 KB

english, 1999